Carl-henrik Heldin
Professor
Department of Medical Biochemistry and Microbiology
Uppsala Biomedical Centre
Sweden
Biography
Carl-Henrik Heldin is a Professor in Department of Medical Biochemistry and Microbiology at Uppsala Biomedical Cente, Sweden. The main interest research lies in the field of Biochemistry and Microbiology and has various publications in the related field.
Research Interest
The research interest of C-H. Heldin is related to the mechanisms of signal transduction by growth regulatory factors, as well as their normal function and role in disease. In particular, platelet-derived growth factor (PDGF), a major mitogen for connective tissue cells, and transforming growth factor β (TGF β), which inhibits the growth of most cell types, are studied. An important goal is to explore the possible clinical utility of signal transduction antagonists.
Publications
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Lönn, P., van der Heide, L., Dahl, M., Hellman, U., Heldin, C. et al. (2010). PARP-1 attenuates Smad-mediated transcription.
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Mu, Y., Sundar, R., Thakur, N., Ekman, M., Kumar Gudey, S. et al. (2011). TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.
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Heldin, C., Moustakas, A. (2012). Role of Smads in TGFβ signaling.
