Christian Sköld
Senior Lecturer
Medicinal Chemistry, Organic Pharmaceutical Chemistry
Uppsala Biomedical Centre
Sweden
Biography
My research is focused within two general research areas in the field of computational medicinal chemistry. One area is to develop and evaluate methods that are useful and effective for medicinal chemistry and drug discovery projects. The second area is to find promising chemical starting points for medicinal chemistry projects and aid in the development of these compounds using computer-aided drug design and multivariate analysis. The latter research area also includes theoretical investigations of reaction mechanisms in pharmaceutically relevant chemical reactions to provide a deep understanding of the reactions and to develop improved reactions protocols and reaction variants useful in the development of drugs or pharmacological probes.
Research Interest
Theoretical investigations of reaction mechanismsto develop improved reactions protocols and reaction variants useful in the development of drugs or pharmacological probes.
Publications
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Lindh M, Svensson F, Schaal W, Zhang J, Sköld C, Brandt P, KarleÌn A. Toward a benchmarking data set able to evaluate ligand-and structure-based virtual screening using public HTS data. Journal of chemical information and modeling. 2015 Jan 28;55(2):343-53.
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Belfrage AK, Gising J, Svensson F, Ã…kerblom E, Sköld C, Sandström A. Efficient and Selective Palladiumâ€Catalysed Câ€3 Urea Couplings to 3, 5â€Dichloroâ€2 (1H)â€pyrazinones. European Journal of Organic Chemistry. 2015 Feb 1;2015(5):978-86.
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Sawant RT, Stevens MY, Sköld C, Odell LR. Microwave-Assisted Branching Cascades: A Route to Diverse 3, 4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds. Organic letters. 2016 Oct 11;18(20):5392-5.
