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Mats Larhed

Professor
Medicinal Chemistry, Organic Pharmaceutical Chemistry
Uppsala Biomedical Centre
Sweden

Biography

Mats Larhed is Professor in Medicinal Chemistry and holds at present the position as Deputy Vice-Rector for the Disciplinary Domain of Medicine and Pharmacy at Uppsala University. Larhed is presently responsible for a number of international projects such as the Pan-European innovation and education initiative EIT Health and the European infrastructure for translational medicine, EATRIS. He serves as Director of the PET medical imaging facility at Uppsala University, he is the SciLifeLab Integration Director at Uppsala University and he is a member of the Board of the Swedish Pharmaceutical Society. Larhed is interested in the development of career paths at universities and he was the Chair of the Uppsala University working group on career paths 2015-16, and he is currently a member of the Q&R17 Research Evaluation Committee. Mats Larheds teaching activities have been directed toward students in pharmacy, chemical engineering and biomedicine. He early developed web-based examinations and lectures for his chemistry courses. He has overseen 16 PhD students to a final doctorate as the main supervisor and is presently supervising five PhD students. Dr Larheds main research interests are: I) design and synthesis of new drugs for treatment of HIV, hepatitis C, malaria and TB, II) development of new chemical methodologies of importance for drug discovery, III) design and high-speed synthesis of novel radiotracers for medical imaging. Larhed has received a number of grants from for example the Knut and Alice Wallenberg Foundation, the Swedish Research Council and the European Commission Framework Programmes as well as a couple of prestigious awards. He has published around 200 scientific articles and a number of approved patents.

Research Interest

I) design and synthesis of new drugs for treatment of HIV, hepatitis C, malaria and TB, II) development of new chemical methodologies of importance for drug discovery, III) design and high-speed synthesis of novel radiotracers for medical imaging.

Publications

  • Gising, J., Odell, L., Larhed, M. (2012). Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C.

  • Motwani, H., De Rosa, M., Odell, L., Hallberg, A., Larhed, M. (2014). Aspartic protease inhibitors containing tertiary alcohol transition-state mimics.

  • Ã…kerbladh, L., Nordeman, P., Wejdemar, M., Odell, L., Larhed, M. (2015). Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source.

  • Russo, F., Gising, J., Ã…kerbladh, L., Roos, A., Naworyta, A. et al. (2015). Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.

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