Ulrika Rosenström
Lecturer
Medicinal Chemistry, Organic Pharmaceutical Chemistry
Uppsala Biomedical Centre
Sweden
Biography
Ulrika received a Master of Science in Chemistry from Uppsala University in 1996 and was appointed as a scientist at Pharmacia and Upjohn. In 1999 she started her dissertation work in Medicinal Chemistry under Prof Anders Hallberg and in 2004 she became Doctor of Philosophy (Faculty of Pharmacy). In 2005 she was appointed a position as researcher and lecturer at the Division of Organic Pharmaceutical Chemistry and 2007 she became Chemistry director and scientist at Cardoz AB, a small biotech company in preclinical and clinical phase. In 2011 she returned to Uppsala University as a researcher and lecturer. Her main research interests are: synthesis of peptides and pseudopeptides as novel PET-radiotracers, and design and synthesis of both drug-like and peptidomimetic enzyme inhibitors.
Research Interest
Synthesis of peptides and pseudopeptides as novel PET-radiotracers, and design and synthesis of both drug-like and peptidomimetic enzyme inhibitors.
Publications
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Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Khan YS, GutieÌrrez-de-TeraÌn H, Sävmarker J, Ng L, Pham V, Lundbäck T, Jenmalm-Jensen A. Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures. ACS chemical neuroscience. 2016 Aug 8;7(10):1383-92.
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Engen K, Rosenström U, Axelsson H, Konda V, Dahllund L, Otrocka M, Sigmundsson K, Nikolaou A, Vauquelin G, Hallberg M, Jenmalm Jensen A. Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening. Assay and drug development technologies. 2016 Apr 1;14(3):180-93.
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Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Khan YS, Gutiérrez-de-Terán H, Ng L, Pham V, Sävmarker J, Lundbäck T, Jenmalm-Jensen A. Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density. Molecular pharmacology. 2016 Apr 1;89(4):413-24.
