Markus Stoffel
Professor
Department of Biology
ETH Zürich - Eidgenössische Technische Hochschule Zürich - Swiss Federal Institute of Technology in Zurich
Switzerland
Biography
Markus Stoffel is currently working as professor, Department of Biology of ETH Zurich.
Research Interest
Integration of extracellular hormonal and nutrient signals into comprehensive gene expression patterns leads to tightly choreographed phenotypic responses that regulate metabolism and cellular differentiation. My overall research interest is to elucidate the fundamental molecular mechanisms that regulate glucose and lipid metabolism through the study of transcriptional and translational regulators that control energy homeostasis in response to physiological (i.e. fasting) and environmental (i.e. caloric excess) stress. Our work focuses on understanding transcriptional and microRNA regulatory networks and their interactions in pancreatic b-cells, liver, fat and hypothalamus. The importance of genetic/genomic regulation in the maintenance of glucose and lipid homeostasis is underscored by the many examples of aberrant signal transduction and transcriptional activation resulting in obesity and type 2 diabetes and the development of secondary complications.
