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Franziska Bleichert


Biology
Friedrich Miescher Institute for Biomedical Research
Switzerland

Biography

2013-2016 Postdoctoral Fellow, Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, USA 2010 - 2013 Miller Research Fellow, Department of Molecular and Cell Biology, University of California at Berkeley, USA 2003 - 2010 Graduate Student, Department of Genetics, Yale University, USA

Research Interest

Our research program is focused on uncovering molecular mechanisms by which the nuclear chromatin landscape impacts different steps of DNA replication. We use an integrated mix of biochemical, biophysical, and structural methods (single-particle cryo-electron microscopy and X-ray crystallography) to identify and visualize key chromatin-associated replication intermediates at atomic or near-atomic resolution

Publications

  • Nodelman IM, Bleichert F, Patel A, Ren R, Horvath KC, Berger JM, Bowman GD (2017) Interdomain communication of the Chd1 chromatin remodeler across the DNA gyres of the nucleosome. Mol Cell. 65:447-459

  • Bleichert F, Botchan MR, Berger JM (2017) Mechanisms for initiating cellular DNA replication. Science. 355 pii: eaah6317

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