Vincent Zoete
Scientist
Ludwig Center at Lausanne
Ludwig Institute for Cancer Research
Switzerland
Biography
The Modeling Group specializes in the development of computer-aided protein engineering (MM-GBSA, CMEPS) and drug design techniques (SwissDock, SwissParam, SwissSideChain, SwissTargetPrediction, SwissBioisostere, SwissSimilarity and SwissADME), applying our research to practical applications in collaboration with a number of research groups. We are currently working on the design and optimization of engineered T-cell receptors—for the immunotherapy of Melanoma—as well as other proteins of the immune synapse. We are also currently designing inhibitors of the indoleamine-2,3-dioxygenase 1 (IDO1), which is overexpressed in many tumors, and ligands of the Stimulator of interferon genes protein (STING).
Research Interest
Protein engineering, drug design, immunotherapy, tumor biology, and cancer genetics.
Publications
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Zoete, Vincent, Markus Meuwly, and Martin Karplus. "Study of the insulin dimerization: Binding free energy calculations and perâ€residue free energy decomposition." Proteins: Structure, Function, and Bioinformatics 61.1 (2005): 79-93.
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Nikolaev, Sergey I., et al. "Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma." Nature genetics 44.2 (2012): 133-139.
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Zoete, Vincent, et al. "SwissParam: a fast force field generation tool for small organic molecules." Journal of computational chemistry 32.11 (2011): 2359-2368.
