Huang Ch
Bio chemistry
National Renewable Energy Laboratory
Switzerland
Biography
Hypoxia Targeting of Hepatocellular Carcinoma with Nitroimidazoles Conjugated to Trimethyl Nordihydroguaiaretic Acid Hepatocellular carcinoma (HCC) develops through cirrhosis brought on by chronic liver injury. This chronic injury results in fibrogenesis that damages the normal liver circulatory system and leads to a shortage of blood perfusion and oxygen delivery. Moreover, in tumor tissues, a high rate of cell proliferation in the tumor cells and abnormalities of structure and function of tumor vessels increases the need for oxygen. We are interested in developing therapies that target hypoxic HCC cells and have been experimenting with nitroimadazoles conjugated to the methylated nordihydroguaiaretic acid (NDGA) anticancer agents developed in our lab.
Research Interest
Hypoxia Targeting of Hepatocellular Carcinoma with Nitroimidazoles Conjugated to Trimethyl Nordihydroguaiaretic Acid Hepatocellular carcinoma (HCC) develops through cirrhosis brought on by chronic liver injury. This chronic injury results in fibrogenesis that damages the normal liver circulatory system and leads to a shortage of blood perfusion and oxygen delivery. Moreover, in tumor tissues, a high rate of cell proliferation in the tumor cells and abnormalities of structure and function of tumor vessels increases the need for oxygen. We are interested in developing therapies that target hypoxic HCC cells and have been experimenting with nitroimadazoles conjugated to the methylated nordihydroguaiaretic acid (NDGA) anticancer agents developed in our lab.
