Jean-philippe Theurillat
Managing Director
Cancer Genomics
Oncology Institute of Southern Switzerland
Switzerland
Biography
2011-2014 Broad Institute of MIT & Harvard and Dana Faber Cancer Institute (Cambridge and Boston, USA), Garraway Laboratory, Research Scientist. 2008-2011 Swiss Institute of Technology (Zurich), Krek Laboratory, Postdoctoral Fellow. 2007 Board Certificate in Surgical Pathology. 2000-2008 Clinical training in Surgical Pathology, Medical Oncology and Internal Medicine (Zurich and Lausanne). 1999 MD Degree, University of Zurich (Switzerland).
Research Interest
(SNFS-professor) My research focuses on how recently identified cancer driver mutations promote tumor growth. In prostate cancer, we discovered a genetically defined subclass of tumors characterized by point-mutations in SPOP (a substrate-binding subunit of a Cullin-based E3 ubiquitin ligase) and deletions in CHD1 (a chromodomain helicase DNA binding protein). Using systematic functional approaches we aim to decipher their precise roles in tumorigenesis with the ultimate goal to develop new therapeutic avenues for this subtype of the disease. Additionally, I’m devoted to develop strategies that enable us to test drug responses on patient-derived tumor cells in a clinical context.
Publications
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Theurillat JP, Metzler SC, Henzi N, Djouder N, Helbling M, Zimmermann AK, Jacob F, Soltermann A, Caduff R, Heinzelmann-Schwarz V, Moch H. URI is an oncogene amplified in ovarian cancer cells and is required for their survival. Cancer cell. 2011 Mar 8;19(3):317-32.
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Theurillat JP, Ingold F, Frei C, Zippelius A, Varga Z, Seifert B, Chen YT, Jäger D, Knuth A, Moch H. NYâ€ESOâ€1 protein expression in primary breast carcinoma and metastases—correlation with CD8+ Tâ€cell and CD79a+ plasmacytic/Bâ€cell infiltration. International journal of cancer. 2007 Jun 1;120(11):2411-7.
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Theurillat JP, Hainfellner J, Maddalena A, Weissenberger J, Aguzzi A. Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. The American journal of pathology. 1999 Feb 28;154(2):581-90.
