Coukos George
Full Professor
Faculty of Biology and Medicine
Universite de Lausanne
Switzerland
Biography
Much of my career as a clinician and cancer researcher has focused on immunotherapy and the exploration of tumor immunology, with a focus on ovarian cancer. In the early 2000’s, my research uncovered the existence of spontaneous immune responses in ovarian tumors and described their influence on the severity of disease. This research suggested that ovarian cancer may be susceptible to immunotherapy, and inspired me to explore the development of such therapies. My laboratory also made critical contributions to our understanding of how tumors exploit regulatory T cells to suppress immune responses, and the role tumor-feeding blood vessels play in such immunosuppression. In parallel, I have also been very involved in the development of novel immunotherapies—including dendritic cell vaccines—and their evaluation in clinical trials related to ovarian cancer.
Research Interest
Tumor Immunology T cell therapies Cancer vaccines Bioinformatics and engineering Clinical trials
Publications
-
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity. Bassani-Sternberg M., Chong C., Guillaume P., Solleder M., Pak H., et al., (2017).
-
Label-free identification of activated T lymphocytes through tridimensional microsensors on chip. Rollo E., Tenaglia E., Genolet R., Bianchi E., Harari A., et al., (2017). 193-199.
-
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. Trabanelli S., Chevalier M.F., Martinez-Usatorre A., Gomez-Cadena A., Salomé B., et al., (2017).
