Desvergne Beatrice
Faculty
Faculty of Biology and Medicine
Universite de Lausanne
Switzerland
Biography
Béatrice Desvergne was trained as a MD. She initially specialized in Anesthesiology and Resuscitation, practiced medicine for a few years, and decided to move for fundamental research. She then carried out a post-doctoral stay from 1988 to 1992 at the National Institutes of Health in Bethesda, first as visiting fellow and then visiting associate in the National Institute of Diabetes and Digestive and Kidney Diseases.
Research Interest
As they mediate intracellular hormone action, nuclear receptors play a crucial multi-faceted role in coordinating growth during development, and homeostasis at adult stage. Among them, the peroxisome-proliferator activated receptors (PPARs) act as fatty acids sensors, responding to dietary as well as to endogenous challenges. Accordingly, they have an integrative role in controlling the expression of genes regulating the storage, mobilization, and/or utilization of lipids. Using various molecular, cellular, and animal approaches, our studies are aimed at understanding how PPARs are integrated in the main pathways that shape the organism during development on the one hand and maintain systemic homeostasis on the other hand.
Publications
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reta MP Giordano Attianese, Béatrice Desvergne Nucl Recept Signal. 2015; 13: e001. Published online 2015 Apr 27. doi: 10.1621/nrs.13001 PMCID: PMC4419664
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Barbara Toffoli, Federica Gilardi, Carine Winkler, Magnus Soderberg, Laura Kowalczuk, Yvan Arsenijevic, Krister Bamberg, Olivier Bonny, Béatrice Desvergne PLoS One. 2017; 12(2): e0171474. Published online 2017 Feb 9. doi: 10.1371/journal.pone.0171474 PMCID: PMC5300244
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Alessia Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W. Hiebert, Maurizio Crestani Nat Commun. 2017; 8: 93. Published online 2017 Jul 21. doi: 10.1038 / s41467-017-00182-7 PMCID: PMC5522415
