Faculty of Biology and Medicine
Universite de Lausanne
Paul Franken received his PhD from the University of Groningen,The Netherlands, in 1993 for his work on sleep homeostasis and thermoregulation at the University of Zurich under the direction of Alexander A. Borbély. He was a postdoctoral fellow with H. Craig Heller at Stanford University, USA, where he studied the cellular mechanisms underlying circadian clock resetting.
In the study of sleep two main regulatory processes have to be considered: a homeostatic process that is activated by and counters the effects of sleep loss and a circadian process that determines the time–of–day sleep preferably occurs. The fine–tuned interaction between the two permits us to stay awake and alert throughout the day and to remain asleep at night. To gain inside into the molecular correlates of the homeostatic process and its interaction with the circadian process we apply a combination of forward, molecular, and reverse genetic approaches in the mouse.
Géraldine M. Mang, Francesco La Spada, Yann Emmenegger, Sylvie Chappuis, Jürgen A. Ripperger, Urs Albrecht, Paul Franken Sleep. 2016 Mar 1; 39(3): 589–601. Published online 2016 Mar 1. doi: 10.5665/sleep.5534 PMCID: PMC4763348
Shanaz Diessler, Corinne Kostic, Yvan Arsenijevic, Aki Kawasaki, Paul Franken eLife. 2017; 6: e23292. Published online 2017 May 26. doi: 10.7554/eLife.23292Includes additional comments & authors PMCID: PMC5464769
Anne Vassalli, Paul Franken Proc Natl Acad Sci U S A. 2017 Jul 3; 114(27): E5464–E5473. Published online 2017 Jun 19. doi: 10.1073/pnas.1700983114 PMCID: PMC5502606