Pich Christine
First assistant
Faculty of Biology and Medicine
Universite de Lausanne
Switzerland
Biography
I am studying melanoma cells physiology and the nuclear hormone receptor PPARγ. So far, we showed that melanoma PPARγ activation induces a pro-inflammatory profile not only in melanoma cells, but also in surrounding fibroblasts and endothelial cells. During my thesis, I studied how pre-treated melanoma cells with statins or Rho GTPases inhibitors upregulate T and/or NK cells ligands. We obtained a reduction of the tumor growth and metastasis in vivo.
Research Interest
Melanoma immunogenicity and promote antiâ€melanoma immune response.
Publications
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Wawrzyniak M, Pich C, Gross B, Schütz F, Fleury S, et al., (2015). Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis. Journal of Allergy and Clinical Immunology. 2015 Jun 30;135(6):1625-35.
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Degueurce G, D'errico I, Pich C, Ibberson M, Schütz F, et al., (2016). Identification of a novel PPARβ/δ/miRâ€21â€3p axis in UVâ€induced skin inflammation. EMBO molecular medicine. 2016 Aug 1;8(8):919-36.
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Sarrabayrouse G, Pich C, Teiti I, Tilkinâ€Mariame AF. (2017). Regulatory properties of statins and rho gtpases prenylation inhibitiors to stimulate melanoma immunogenicity and promote antiâ€melanoma immune response. International journal of cancer. 2017 Feb 15;140(4):747-55.
