Dr. Achim Stocker
Associate Professor
Department of Chemistry and Biochemistry
Universität Bern
Switzerland
Biography
Dr. Achim Stocker from 1979 - 1986: Studies in Biochemistry, University of Zurich. Diploma thesis on "Differential Chemical Modification of Cytochrome-c" in the lab of Prof. HR Bosshard 1986 - 1992: Awarded PhD Thesis in Chemistry at the University of Zurich: "Identification and Isolation of the Tocopherol Cyclase of Anabaena Variabilis Kützing" (supervisor Prof. W.-D. Woggon) 1993 - 1996: Postdoctoral research at the Society for Biotechnological Research (GBF) Braunschweig, Germany. "Synthesis and crystallization of semi-synthetic D-amino acid oxidase for X-ray crystallography and biosensor applications" 1996 - 2000: Postdoctoral research fellow at the Institute of Biochemistry and Molecular Biology, University of Berne. "In-vitro expression and characterization of human tocopherol-binding proteins" 2001 - 2003: Postdoctoral research fellow at the Department of Chemistry and Biochemistry, University of Bern. "Structure determination of human lipid transfer proteins" 2003 - 2006: Research group leader in the group of Prof. Peter Dimroth at the Institute of Microbiology, ETHZ. "Functional and structural investigations on the ATP synthase of bacillus sp. TA2 " Since 2006: Lecturer and group leader at the Department of Chemistry and Biochemistry, University of Berne. "Structural and functional studies on lipid carriers associated with retinopathies and neurological disorders" Since 2014: associate professor in biochemistry at the University of Bern (associate professor)
Research Interest
Our goal is to help you understand the linkage between dysfunctional SEC14-like proteins and human diseases. In particular, we try to understand how members of the SEC14-like family of proteins recognize and shuttle specific lipids between compartments. Besides the biophysical aspects of targeted lipid transfer, we aim to understand how human retinopathies and neurological disorders are associated with missense mutations of the carriers.
Publications
-
Wagner, Anika ; Piegholdt, Stefanie ; Raven, Doerte ; Baenas, Nieves ; Castles, Anke ; Eggersdorfer, Manfred ; Stocker, Achim ; Rimbach, Gerald (2015). Epigallocatechin gallate (EGCG) affects glucose metabolism and enhances fitness and life span in Drosophila melanogaster. OncoTarget, 6 (31), pp. 30568-30578. Impact Journals LLC 10.18632 / oncotarget.5215
-
Bergmann, Myriam ; Michaud, Gaëlle ; Visini, Ricardo ; Jin, Xian ; Gillon, Emilie ; Stocker, Achim ; Imberty, Anne ; Darbre, Tamis ; Reymond, Jean-Louis (2015). Multivalency effects in Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. Organic & biomolecular chemistry, 14 (1), pp. 138-148. Royal Society of Chemistry 10.1039 / C5OB01682G
-
Michaud, Gaëlle ; Visini, Ricardo ; Bergmann, Myriam ; Salerno, Gianluca ; Bosco, Rosa ; Gillon, Emilie ; Richichi, Barbara ; Nativi, Cristina ; Imberty, Anne ; Stocker, Achim ; Darbre, Tamis ; Reymond, Jean-Louis (2016). Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. Chemical Science, 7 (1), pp. 166-182. The Royal Society of Chemistry 10.1039 / c5sc03635f
-
Röthlisberger, Pascal ; Istrate, Alena ; Marcaida Lopez, MJ ; Visini, Ricardo ; Stocker, Achim ; Reymond, Jean-Louis ; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrene pair. Chemical communications, 52 (26), pp. From 4749 to 4752. Royal Society of Chemistry 10.1039 / c6cc00374e
-
Probst, Markus ; Aeschimann, Walter ; Chau, Thi TH ; Langenegger, Simon Matthias ; Stocker, Achim ; Häner, Robert (2016). Structural insight into DNA-assembled oligochromophores: crystallographic analysis of pyrene- and phenanthrene-modified DNA in complex with BpuJI endonuclease. Nucleic acids research, 44 (15), pp. 7079-7089. Information Retrieval Ltd. 10.1093 / nar / gkw644
