Dr. Christian Leumann
Professor
Department of Chemistry and Biochemistry
Universität Bern
Switzerland
Biography
Dr. Christian Leumann from 1977 - 1981 graduate studies in chemistry, Federal Institute of Technology (ETH) Zurich (Switzerland); 1982 - 1986 Ph.D. thesis "Biomimetic C-methylation reactions on cor- quer derivatives" at ETH (Prof. Albert Eschenmoser). A model study related to the sequence of the methylation steps in vitamin B12 biosynthesis; 1987 - 1988 Post-doc at the Chemistry Department, University of California, Berkeley (Prof. Peter G. Schultz). Synthesis and characterization of catalytic antibodies. 1988 - 1993 Senior Assistant at the Laboratory of Organic Chemistry, ETH. Research work concerned the nucleic acid analogues. 1993 - Professor of Bioorganic Chemistry at the Department of Chemistry and Biochemistry, University of Berne, (Switzerland). 2001 Sabbatical stay (7 months) at the Scripps Research Institute in La Jolla (USA). 2011 Sabbatical stay (3 months) at the Stanford University in Palo Alto (USA)
Research Interest
Oligonucleotides therapeutics; Oxidatively damaged RNA; DNA materials
Publications
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Röthlisberger, Pascal ; Istrate, Alena ; Marcaida Lopez, MJ ; Visini, Ricardo ; Stocker, Achim ; Reymond, Jean-Louis ; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrene pair. Chemical communications, 52 (26), pp. From 4749 to 4752. Royal Society of Chemistry 10.1039 / c6cc00374e
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Schuermann, David ; Scheidegger, Simon P .; Weber, Alain R .; Bjørås, Magnar ; Leumann, Christian J .; Schär, Primo (2016). 3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair. Nucleic acids research, 44 (5), pp. 2187-2198. Information Retrieval Ltd. 10.1093 / nar / gkv1520
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Röthlisberger, Pascal ; Kaliginediand, Veerabhadrarao ; Leumann, Christian (2017). Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates. Chemistry: a European journal, 23 (9), pp. 2022-2025. Wiley 10.1002 / chem.201605846
