Dr. Martin Lochner
Professor
Department of Chemistry and Biochemistry
Universität Bern
Switzerland
Biography
Dr. Martin Lochner from 1993 - 1998: Diploma in Chemistry, University of Zurich. Diploma thesis: synthesis of unnatural polyamines (group of late Prof. Dr. Manfred Hesse). 1998 - 2003: PhD thesis, University of Basel. Synthesis and study of iron porphyrin model compounds as mimics for cytochrome P450 enzymes (group of Prof. Dr. em. Wolf-D. Woggon). 2003 - 2004: Postdoctoral Research Fellow with Prof. Ian Paterson FRS, Department of Chemistry, University of Cambridge, UK. Working on the total synthesis of the marine, anti-cancer compound Peloruside A. 2004 - 2005: Postdoctoral Research Fellow with Prof. Sarah CR Lummis, Department of Biochemistry, University of Cambridge, UK. Study of mutant serotonin 5-HT3 receptors as models for heteromeric ligand-gated ion channels. 2006 - 2009: Lecturer in Chemical Biology, Department of Chemistry, University of Warwick, UK. 2010 - 2015: Swiss National Science Foundation Professor (Assistant Professor) in Bioorganic Chemistry, Department of Chemistry & Biochemistry, University of Bern. 2016 - present: Lecturer and Group Leader at the Institute of Biochemistry and Molecular Medicine (IBMM), University of Bern.
Research Interest
1. Fluorescent receptor ligands (antagonists and agonists) 2. Photo-crosslinking probes 3. Fluorescent turn-on probes for protein labelling
Publications
-
Leuenberger, Michele ; Ritler, Andreas ; Simonin, Alexandre ; Hediger, Matthias ; Lochner, Martin (2016). Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. ACS chemical neuroscience, 7 (5), pp. 534-539. American Chemical Society 10.1021 / acschemneuro.5b00311
-
Lochner, Martin ; Thompson, Andrew James (2016). The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology, 108, pp. 220-228. Elsevier 10.1016 / j.neuropharm.2016.04.027
-
Mu, Linjing ; Muellerherde, Adrienne ; Rüefli, Pascal ; Sladojevich, Filippo ; Sephton, Selena Milicevic ; et al (2016). Synthesis and Pharmacological Evaluation of [11C] granisetron and [18F] fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging. ACS chemical neuroscience, 7 (11), pp. 1552-1564. American Chemical Society 10.1021 / acschemneuro.6b00192
-
Thompson, Andrew J .; Butcher, Simon ; Lochner, Martin ; Ruepp, Marc-David (2017). The binding orientation of epibatidine at α7 nACh receptors. Neuropharmacology, 116, pp. 421-428. Elsevier 10.1016 / j.neuropharm.2017.01.008
-
Ruepp, Marc-David ; Wei, Hao ; Leuenberger, Michele ; Lochner, Martin ; Thompson, Andrew James (2017). The binding orientation of structurally-related ligands can differ; A cautionary note. Neuropharmacology, 119, pp. 48-61. Elsevier 10.1016 / j.neuropharm.2017.01.023
