Dr. Oliver Mühlemann
Professor
Department of Chemistry and Biochemistry
Universität Bern
Switzerland
Biography
Dr. Oliver Mühlemann from 1987-1992: Studies in Biology at the University of Bern (Switzerland). Diploma thesis on U7 snRNA expression in the laboratory of Daniel Schümperli, Institute of Zoology. 1992-1998: Ph.D. In the lab of Göran Akusjärvi at the Cell and Molecular Biology Department, Karolinska Institute, Stockholm (Sweden) and later at the Biomedical Center, Uppsala University (Sweden). Work on the regulation of alternative splicing in adenovirus. 1998-1999: Postdoctoral work in the laboratory of Melissa Moore, HMMI / Brandeis University, Waltham, MA (USA). Research on the mechanism of nonsense-mediated RNA. 2000-2009: Research group leader at the Institute of Cell Biology, University of Bern (Switzerland). Research on mRNA quality control. Research Fellow of the Cloëtta Foundation 2005-2009. Starting Grant of the European Research Council (ERC) awarded in 2007. Since 2010: Full professor of Biochemistry at the Department of Chemistry and Biochemistry, University of Bern. Since 2014: Director of the NCCR RNA & Disease
Research Interest
We are investigating post-transcriptional gene regulation in human cells with a particular emphasis on the deciphering of the molecular mechanism and the biological and medical implications of nonsense-mediated mRNA decay (NMD). NMD is an important mRNA quality control process that recognizes and degrades mRNPs that fail to properly terminate translation, but also regulate expression levels of many physiological mRNAs.
Publications
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Schwingruber, Christoph ; Soffientini, Paolo ; Ruepp, Marc-David ; Bachi, Angela ; Millmann, Oliver (2016). Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID). PLoS ONE, 11 (3), e0150239. Public Library of Science 10.1371 / journal.pone.0150239
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Karousis, Evangelos ; Nasif, Sofia ; Millmann, Oliver (2016). Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact. Wiley Interdisciplinary Reviews: RNA, 7 (5), pp. 661-682. Wiley 10.1002 / wrna.1357
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Reber, Stefan ; Stettler, Jolanda ; Filosa, G .; Colombo, Martino ; Jutzi, D .; Lenzken, SC ; Schwingruber, Christoph ; Bruggmann, Rémy ; Bachi, A .; Barabino, SM ; Mühlenmann, Oliver ; Ruepp, Marc-David (2016). Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants. EMBO journal, 35 (11) Nature Publishing Group 10.15252 / embj.201593791
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Colombo, Martino ; Karousis, Evangelos D .; Bourquin, Joëll ; Bruggmann, Rémy ; Mühlenmann, Oliver (2017). Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6 and SMG7-mediated degradation pathways. RNA - a publication of the RNA Society, 23 (2), pp. 189-201. Cold Spring Harbor Laboratory Press 10.1261 / rna.059055.116
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Balistreri, Giuseppe ; Bognanni, Claudia ; Mühlenmann, Oliver (2017). Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay. Viruses, 9 (1) Molecular Diversity Preservation International MDPI 10.3390 / v9010024
