Guarda Greta
Faculty of Biology and Medicine
Department of Biochemistry
University of Lausanne
Switzerland
Biography
Greta Guarda studied Molecular Biology at the University of Zurich and at the Swiss Federal Institute of Technology. She carried out her PhD work on T cell trafficking under the supervision of Federica Sallusto and Antonio Lanzavecchia at the Institute for Research in Biomedicine, Bellinzona. In 2007, she joined the group of Jürg Tschopp at the University of Lausanne as a post-doctoral fellow, and focused her research on NOD-like receptors in the context of inflammasome function. She was appointed senior lecturer in 2010 and Assistant Professor funded by the Swiss National Science Foundation in 2012. Her current research focuses on the function of NOD-like receptors that are highly expressed, but poorly characterized, in adaptive immune cells.
Research Interest
PATTERN RECOGNITION RECEPTORS IN INNATE AND ADAPTIVE IMMUNITY In innate immune cells, the expression of pattern recognition receptors (PRRs), such as NOD-like receptors (NLRs), is crucial for early detection of endogenous stress signals or infections.
Publications
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Chelbi ST, Guarda G. (2016). NLRC5, a promising new entry in tumor immunology. Journal for immunotherapy of cancer. 2016 Jul 19;4(1):39.
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Ludigs K, Jandus C, Utzschneider DT, Staehli F, Bessoles S, et al., (2016). NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nature communications. 2016;7.
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Dang AT, Pasquali C, Ludigs K, Guarda G. (2017). OM-85 is an immunomodulator of interferon-β production and inflammasome activity. Scientific Reports. 2017;7.
