Luther Sanjiv
Faculty of Biology and Medicine
Department of Biochemistry
University of Lausanne
Switzerland
Biography
Sanjiv Luther studied cell biology at the ETH in Zürich. He received his PhD in 1996 from the University of Lausanne for his work on anti-viral immune responses in the laboratory of Hans Acha-Orbea. He then moved to the laboratory of Jason Cyster at the Howard Hughes Medical Institute at the University of California San Francisco where he investigated the role of chemotactic factors in lymphoid tissue development and function. In 2003 he joined the Department of Biochemistry as Assistant Professor funded by a career-development award from the Swiss National Science Foundation. Since 2009 he is Associate Professor. His current research focuses on the characterization of fibroblastic stromal cells found within secondary lymphoid organs and sites of chronic inflammation.
Research Interest
LYMPHOID TISSUE STROMAL CELLS IN HEALTH AND DISEASE Secondary lymphoid tissues, such as lymph nodes and spleen, are sites specialized in the initiation and regulation of adaptive immune responses. It is within the T cell rich zone of these organs that dendritic cells (DC) present the captured pathogens to recirculating T cells in order to activate the rare antigen-specific T cells.
Publications
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Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, et al., (2017). Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. The Journal of clinical investigation. 2017 Apr 3;127(4):1574-88.
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Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, et al., (2017). Essential role of CCL21 in establishment of central self-tolerance in T cells. Journal of Experimental Medicine. 2017 Jun 13:jem-20161864.
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Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL. (2017). Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis. Nature Communications. 2017;8.
