Thome Miazza Margot
Faculty of Biology and Medicine
Department of Biochemistry
University of Lausanne
Switzerland
Biography
Margot Thome studied Biochemistry at the University of Tübingen and the University of Arizona, and carried out her PhD work in the laboratory of Oreste Acuto at the Pasteur Institute in Paris. As a postdoctoral fellow she worked with Jürg Tschopp at the University of Lausanne, where she identified human and viral FLIP proteins as key apoptosis regulators. She became Assistant Professor of the Swiss National Science Foundation at the Department of Biochemistry of the University of Lausanne in 2004, and was appointed Associate Professor in 2009. Since 2015 she is the Deputy Director of the Department
Research Interest
Lymphocytes play a crucial role in the defense against pathogens and tumor cells. One focus of our research is to understand the molecular mechanisms that control the activation of T-lymphocytes, initiated upon triggering of the T-cell antigen receptor by MHC-bound antigen. This leads to the initiation of multiple signaling pathways that regulate changes in cell shape and gene expression that are critical for efficient T-cell activation, proliferation and survival.
Publications
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Vallois D, Dobay MP, Morin RD, Lemonnier F, Missiaglia E, et al., (2016). Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas. Blood. 2016 Sep 15;128(11):1490-502.
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Dai B, Grau M, Juilland M, Klener P, Höring E, et al., (2017). B-cell receptor–driven MALT1 activity regulates MYC signaling in mantle cell lymphoma. Blood. 2017 Jan 19;129(3):333-46.
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Bonsignore L, Passelli K, Pelzer C, Perroud M, Konrad A, et al., (2017). A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma. Leukemia. 2017 Mar;31(3):614.
