Widmann Christian
Faculty of Biology and Medicine
Department of Physiology
University of Lausanne
Switzerland
Biography
Christian Widmann obtained in 1991 his PhD at the department of biochemistry at the University of Lausanne, He then did a first post-doc in the laboratory of Prof. Bernard Thorens in Lausanne and then a second one in the laboratory of Prof. Gary Johnson at the National Jewish Center in Denver. He came back to Switzerland in 1999 where he started his own lab as an independent group leader at the CHUV. In 2002, he got an assistant professorship position in the Department of Cell Biology, UNIL. Since 2006, he is an Associate Professor within the Department of Physiology, UNIL.
Research Interest
Reseach interest focuses on a stress-sensing molecular device made of the caspase-3/p120RasGAP pair that allows cells determining whether they should survive or die (see our recent review in Trends in Cell Biology). We also work on HDL-mediated pancreatic beta cell survival and on an anti-cancer RasGAP-derived peptide.
Publications
-
Tsoutsou P, Annibaldi A, Viertl D, Ollivier J, Buchegger F, et al., (2017). TAT-RasGAP317–326 Enhances Radiosensitivity of Human Carcinoma Cell Lines In Vitro and In Vivo through Promotion of Delayed Mitotic Cell Death. Radiation Research. 187: 562-569.
-
Vanli G, Sempoux C, Widmann C. (2017). The caspaseâ€3/p120 RasGAP stressâ€sensing module reduces liver cancer incidence but does not affect overall survival in gammaâ€irradiated and carcinogenâ€treated mice. Molecular Carcinogenesis. 56: 1680-1684.
-
Regazzi R, Widmann C. (2017). Fatty acid metabolism regulates cell survival in specific niches. Current Opinion in Lipidology. 28: 284-285.
