Don B. Axworthy

Biography

Don is the Sr. Director of In Vivo Pharmacology, responsible for leading a dedicated group of Global Technical Directors specializing in selected therapeutic area drug development. For the past 7 years, Don has worked with this team to maintain and broaden a highly relevant portfolio of therapeutic efficacy and liability models. The group's combined consultative expertise and therapeutic area experience and specializations regularly contribute to our partners' compound discovery and development. The group emphasizes progressive evaluation through all level of pharmacodynamics testing, from activity screens and rank-ordering of candidates, to lead identification, selection, and translational studies. Don's industry experience includes Section Head of Pharmacology, Clinical Pharmacokinetics and Drug Metabolism at NeoRx Corporation, Chief Scientific Officer of Aletheon Pharmaceuticals and a Staff Scientist in the lab of Dr. Oliver Press at the Fred Hutchinson Cancer Center. He has over 20 years of experience in the field of targeted cancer therapy and rodent models development, and human clinical trial design, and has worked with in vitro and in vitro modeling of metabolism and pharmacokinetics for both small molecules and biologics. He has written the preclinical Pharmacology and Clinical Trial Design sections of six Phase I/II INDs and two multi‐centered Phase II INDs. As the inventor of 20 issued U.S. or foreign patents he is one of the leading authorities on the application of multi‐step radioisotope targeting for the treatment of cancer.

Research Interest

Pharmacology