Microbiology and Immunology
National Health Research Institutes
Hsin-Wei Chen has initiated the development of dengue vaccines project in NHRI. His team has developed a novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity. Most important, they developed recombinant lipidated dengue subunit vaccine candidates. These candidates independently stimulate long-lasting neutralizing antibodies and reduce the risk of antibody-dependent enhancement. The immune responses induced by the tetravalent formulation in the absence of the exogenous adjuvant are functional in clearing the 4 serotypes of dengue virus in vivo.
Vaccines and Immunology