Hsin-fu Chen
Professor
Medical Genomics and Proteomics
National Taiwan University
Taiwan
Biography
In the past years, Dr. Chen continues the past research interests, focusing primarily on topics related to infertility treatment, human reproductive endocrinology, such as polycystic ovary syndrome (PCOS), embryonic development and human pluripotent stem cells, including human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. Firstly in 2004, under the supervision by Prof. Ho (Hong-Nerng Ho), Dr. Chen’s lab has derived 3 human ES cell lines of Taiwanese ancestry. These 3 cell lines had been well characterized about the morphology, growth speed, karyotypes, in vivo and in vitro differentiation potential, gene expression profiles and telomerase activity etc. Specifically these cells were proved to be capable of differentiating into germ cell lineage, including the development into ovarian follicle-like structures and the expression of germ cell markers, including VASA and SCP3 etc. This paper was published in Feb issue of Human Reproduction 2007 and the Figures in the paper was selected as the cover figures of this specific issue (please refer to figure). These studies confirmed that these human ES cell lines will be most useful cell for future pluripotent stem cell study. Dr. Chen’s lab is continuously working hard on this topic, and hopefully a useful experimental model, development from stem cells to germ cells, can be established for subsequent study on testing chemicals to improve human germ cell development and survival. Now further study on stem cell to germ differentiation by using a transgenic Oct4-eGFP H9 human ES cell line has been completed and the paper will be submitted within 2 weeks.
Research Interest
reproductive endocrinology, biology of pluripotent stem cells, infertility obstetrics and gynecology
Publications
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Huang CC, Chang LJ, Chen HF*, Chen SU*,2014,Response to: "Preimplantation genetic diagnosis strategy combining blastocyst biopsy and array comparative genomic hybridization for parents carrying chromosomal translocation"., J Formos Med Assoc,113,11,pp883-884 (SCI)
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Mo CF, Wu FC, Tai KY, Chang WC, Chang KW, Kuo HC, Ho HN, Chen HF, Lin SP.,2014,Expression of imprinted noncoding RNA from the dlk1-dio3 locus in human embryonic stem cells advantages neural lineage differentiation.,Fertility and Development,27,1,pp261-261 (SCI)
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Mo CF, Wu FC, Tai KY, Chang WC, Chang KW, Kuo HC, Ho HN, Chen HF, Lin SP.,2015,Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines.,Stem Cell Res Ther,6,1,pp1-1 (SCI)
