Yi-cheng Chang
Assistant Professor
Medical Genomics and Proteomics
National Taiwan University
Taiwan
Biography
The main research focus of our team is (1) human and mouse genetic studies for type 2 diabetes, obesity, and related metabolic traits (2) translational research of type 2 diabetes and obesity. We aimed to identify genetic loci for type 2 diabetes, obesity, and related metabolic traits in human. We further validated these findings in genetically modified mice model and dissected molecular mechanisms underlying the associations. We are currently trying to develop small-molecules for treatment for type 2 diabetes and obesity. We hope these efforts can be translated to clinical therapy for patients with type 2 diabetes and obesity. Our current research projects include: 1.Genome-wide linkage or association approaches to identify genetic loci for type 2 diabetes, obesity, and related metabolic traits in human using case-control or family design. 2.Generation of transgenic mice to validate our findings from human genetics and to dissect molecular mechanisms. Based on the identified mechanism, we thought to screen small molecules for treatment. 3.Current, we identify possible targets to treat type 2 diabetes and obesity including enzymes involved in aldehydes and prostaglandins metabolism as well as redox control.
Research Interest
Human and mouse genetic study for diabetes, obesity, and hypertension
Publications
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Chang CH, Lin JW, Chen ST, Lai MS, Chuang LM, Chang YC*.,2016,Dipeptidyl peptidase-4 use is not associated with acute pancreatitis in high-risk diabetic patients: a nationwide cohort study.,Medicine,95,7,ppe2603- (SCI)
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Chang TJ, Tseng HC, Liu MW, Chang YC, Hsieh ML, Chuang LM*,2016,Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressingprolonged AMPK activation,Scientific Report ,6,pp23403- (SCI)
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Chang TJ, Wang WC, Hsiung CA, He CT, Lin MW, Sheu WH, Chang YC, Quertermous T, Chen I, Rotter J, Chuang LM*,2016,Genetic variation in the human SORBS1 gene is associated with blood pressure regulation and age at onset of hypertension: a SAPPHIRe cohort study.,Medicine,95,10,ppe2970- (SCI)
