Yunsheng Hsieh

Biography

 Dr. Hsieh received his Ph.D. from Chemistry Department of Michigan State University. Prior to joining Schering Plough Research Institute, he did postdoctoral training at the Department of Pharmacology and Biochemistry of the University of Florida and at the Biopharmaceutical Sciences Department of the University of California-San Francisco. During his tenure at Drug Metabolism and Pharmacokinetics (DMPK) Department of legacy Schering-Plough Research Institute/Merck Research Laboratories, Dr. Hsieh lead a strong bioanalytical group composed of Ph.D., M.Sc. and B.Sc. scientists to apply challenging UPLC-MS/MS approaches for metabolite identification and sub-nanogram/ml quantitative assays of a variety of molecules and also served as a project manager to conduct in vitro and in vivo exploratory DMPK experiments for a variety of drug discovery programs such as TRA, HCV, NAR, CHK1 and to present the results in collaboration with medicinal chemistry and biology departments to support drug discovery projects. Dr. Hsieh is currently Chief Scientific Officer at Protech Pharmaservices Corporation.

Research Interest

 Dr. Hsieh’s research interests are in the areas of biological mass spectrometry (MS). The major objectives of the research are to expand the bioanalytical horizons through developing mass spectrometry-based techniques for the characterization and quantitation of known and/or unknown chemicals and then to utilize these capabilities to study the real-world biomedical systems. Dr. Hsieh’s research activities will mainly include the following projects: (1) Development of bioanalytical methods using matrix-assisted laser desorption ionization (MALDI) or electrospray ionization (ESI) coupled to MS for macromolecule analysis. (2) Development of hyphenated-tandem mass spectrometric (MS/MS) methods interfaced with various atmospheric pressure ionization methods for small molecules and biomarkers analysis.