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Microbiology Experts

James Fleckenstein

Associate Professor
Molecular Microbiology
Washburn Institute of Technology
United Arab Emirates

Biography

Research in our laboratory focuses on the molecular pathogenesis of enterotoxigenic Escherichia coli (ETEC). These organisms are a major cause of mortality in young children due to diarrheal illness in developing countries, and are perennially the most common etiology of diarrhea in travelers. ETEC constitute a diverse E. coli “pathotype” that share in the ability to effectively deliver heat-labile (LT) and/or heat-stable (ST) toxins to respectively activate cAMP and cGMP production in host intestinal cells.

Research Interest

Studies in the lab use a variety of molecular techniques and in vitro and in vivo models to elucidate the role of novel virulence factors in several key steps essential in the pathogenesis of these organisms: bacterial adhesion, intestinal colonization, and finally toxin delivery. Projects involving genome, transcriptome, and immuno-proteome analysis of these pathogens seek to accelerate identification of potential vaccine targets. The principal long-term goal of these studies is to provide additional molecular details to aid rational selection of target antigens and inform future vaccine development efforts for these important pathogens.

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