Thomas Manfred Helmut Caspari
Director of NWCRF Institute
School of Medical Sciences
Bangor University
United Kingdom
Biography
One of the earliest signs of cancer development is genomic instability which appears to be caused by aberrant DNA replication. Changes to cell cycle regulation and to signal transduction pathways may promote unscheduled cell proliferation resulting in changes to the genetic information. However, little is known about how cells regulate the different DNA repair pathways in order to maintain their genetic information while they progress through the cell cycle. In the current research programmes, we use the fission yeast Schizosaccharomyces pombe as a model organism to reconstruct what may happen in human cancer cells at an early stage of their malignant transformation.
Research Interest
fission yeast Schizosaccharomyces pombe as a model organism to reconstruct what may happen in human cancer cells at an early stage of their malignant transformation.
Publications
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Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe Caspari, T. M., Caspari, T. & Hilditch, V. 1 Jul 2015 In : PLoS ONE.
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Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity Murphy, P., Evans, D., Fituri, H., Caspari, T., Cartmell, C., Elwood, J. M. L., Poniedziałekc, B. & Rzymskic, P. 10 Jul 2017 In : Toxicology in Vitro.
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A novel CTX-M14 related beta-lactamase renders E.coli sensitive to the antibiotic Nitrofurantoin used to treat Urinary Tract Infections Caspari, T., Al-Mehdi Edowik, Y. & Williams, M. 31 Jul 2017
