Jeremy Carlton

Biography

I obtained a B.A. in Natural Sciences from Cambridge University and then a Ph.D from the University of Bristol, under the direction of Prof Pete Cullen. During this time, I examined membrane trafficking pathways regulated by the phosphoinositide-binding family of Sorting Nexins. After my Ph.D, I moved to the laboratory of Prof Juan Martin-Serrano in the Infectious Diseases department of King's College London to examine how the ESCRT-machinery is hijacked by HIV-1 to allow its release from infected cells. Here, as a Beit Memorial Fellow for Medical Research, I described a novel and unexpected role for the ESCRT-machinery in cytokinesis and characterised the involvement of ESCRT-III proteins in an Aurora-B regulated abscission checkpoint.

Research Interest

The Endosomal Sorting Complex Required for Transport (ESCRT) machinery is an evolutionarily-conserved, multi-subunit membrane remodeling complex. Originally identified in yeast for its essential role in the biogenesis of intraluminal vesicles (ILVs) upon a class of endosome called the multivesicular body (MVB), its roles in mammalian cells have been expanded to encompass a number of topologically equivalent membrane remodeling events including release of enveloped retroviruses, completion of the abscission phase of cytokinesis and reformation of the nuclear envelope during mitotic exit