Paul Yeo
Visiting Lecturer
School of Medicine, Pharmacy and Health
Durham University
United Kingdom
Biography
Paul was appointed as Lecturer in Microbiology in 2004 after seven years working in the renowned Medical Research Council’s Virology Unit (Glasgow) as a senior scientist. Prior to that, he worked in the University of Reading on HIV. His current research interests are focussed on Respiratory Syncytial Virus (RSV) a major cause of respiratory disease in infants and the elderly. Throughout his research career Paul has focused upon the study of viral proteins for their structure, function and ultimately to use this information in the design of novel therapeutics. The results of this work will lead to a greater understanding of how viruses replicate and cause disease. He has identified potential targets for intervention particularly against the interaction between the RSV nucleocapsid and the polymerase. Further work on validating these targets as therapeutics is ongoing but they provide proof of principle that there are alternative strategies to be taken in the search for new reagents.
Research Interest
Cell Biology, Membrane:Protein interactions, Molecular Biology, Structural Biology, Virology.
Publications
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Money, V.A. McPhee, H.K. Mosely, J.A., Sanderson, J.M. & Yeo, R.P. (2009). Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction. Proceedings of the National Academy of Sciences, USA 106(11): 4441-4446.
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Curtis F.A., Reed, P., Wilson, L.A., Bowers, L.Y., Yeo, P., Sanderson, J.M., Walmsley, A.R. & Sharples, G.J. (2011). The C-terminus of the phage lambda Orf recombinase is involved in DNA binding. Journal of Molecular Recognition 24(2): 330-340.
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McPhee, H.K., Carlisle, J.L., Beeby, A., Money, V., Watson, M.D., Yeo, R.P. & Sanderson, J.M. (2011). Influence of Lipids on the Interfacial Disposition of Respiratory Syncytical Virus Matrix Protein. Langmuir 27(1): 304-311.
