Dominique Bonnet
oncology
Francis Crick Institute
United Kingdom
Biography
After obtaining a PhD degree in the University of Paris VII in 1993, Dominique Bonnet joined as a research fellow the group of Professor John Dick's laboratory in Toronto, Canada. She worked there on establishing an in vivo model to study human acute myeloid leukaemia and identified leukemic stem cells. In 1998, she accepted a position as Group Leader at the Coriell Institute for Medical Research, in New Jersey and became Assistant Professor, University of Medicine and Dentistry of New Jersey. In 2001, she moved to London at the Imperial Cancer Research Fund (ICRF; which became Cancer Research UK in 2002). In 2006, she became a Senior Group Leader at the London Research Institute (now part of the Francis Crick Institute). Since August 2002, she is also Professor at the University College of London, division of Biosciences, and a Senior Lecturer at the Institute of Child Health.
Research Interest
Her group is investigating the molecular programs that regulate both human normal and leukemic stem cells. She is also interested in deciphering the role played by the microenvironment or niche in this regulation and finding new potential targets to eradicate the leukemic stem cell pool.
Publications
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Rouault-Pierre K, Onieva Lopez L, et al. HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress. Cell Stem Cell; 2013:13 (5): 549-63
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Anjos-Afonso F, et al. CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell; 2013; 13(2):161-174.
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Pizzitola I et al. Chimeric Antigen Receptors against CD33/CD123 antigens specific target primary Acute Myeloid Leukemia cells in vivo. Leukemia, 2014,28(8):1596-605.
