Eva Frickel
Biochemistry
Francis Crick Institute
United Kingdom
Biography
Eva grew up in Germany and the United States and obtained a BSc in chemistry from the University of Freiburg in Germany before moving to Uppsala University in Sweden to study enzyme kinetics and complete an MSc in biochemistry. After a short research assistant position in a protein crystallography lab in Auckland, New Zealand, Eva pursued a PhD with Ari Helenius at the ETH Zurich in Switzerland. Eva was awarded a Research Career Development Fellowship and the Wellcome-Beit Prize both from the Wellcome Trust to transfer her research to the Medical Research Council's National Institute for Medical Research (now part of the Francis Crick Institute).
Research Interest
She studied glycoprotein folding in the endoplasmic reticulum and was interested in the mechanisms of glycoprotein chaperones and their associated thiol-disulfide oxidoreductase.
Publications
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Clough, B; Wright, JD; Pereira, PM; Hirst, EM; Johnston, AC; Henriques, R and Frickel, E-M (2016) K63-linked ubiquitination targets Toxoplasma gondii for endo-lysosomal destruction in IFNγ-stimulated human cells. PLOS Pathogens 12, e1006027
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Foltz, C; Napolitano, A; Khan, R; Clough, B; Hirst, EM and Frickel, E-M (2017) TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles. Scientific Reports 7, 5209
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Clough, B and Frickel, E-M (2017) The Toxoplasma parasitophorous vacuole: an evolving host-parasite frontier. Trends in Parasitology 33, 473-488
