Martin Singleton
Biochemistry
Francis Crick Institute
United Kingdom
Biography
Martin Singleton carried out his PhD on the characterisation and applications of enzymes involved in stereoselective organic synthesis, in the Department of Chemistry at the University of Exeter. He then moved to the laboratory of Dale Wigley at the Sir William Dunn School of Pathology in Oxford, where his work focused on the structure and mechanism of DNA helicases. He moved with the Wigley group to the Cancer Research UK Clare Hall laboratories in 2000, where he continued his helicase interests, before establishing his own lab at the London Research Institute in 2005 (now part of the Francis Crick Institute). There, his group has been studying the proteins that constitute the kinetochore and, more recently, the sister chromatid cohesion apparatus.
Research Interest
the structure and mechanism of DNA helicases
Publications
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Sansregret, L; Patterson, JO; Dewhurst, S; López-GarcÃa, C; Koch, A; McGranahan, N; Chao, WCH; Barry, DJ; Rowan, A; Instrell, R; Horswell, S; Way, M; Howell, M; Singleton, MR; Medema, RH; Nurse, P; Petronczki, M and Swanton, C (2017) APC/C dysfunction limits excessive cancer chromosomal instability. Cancer Discovery 7, 218-233
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Chao, WCH; Wade, BO; Bouchoux, C; Jones, AW; Purkiss, AG; Federico, S; O'Reilly, N; Snijders, AP; Uhlmann, F and Singleton, MR (2017) Structural basis of Eco1-mediated cohesin acetylation. Scientific Reports 7, 44313
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Chao, WCH; Murayama, Y; Muñoz, S; Jones, AW; Wade, BO; Purkiss, AG; Hu, X-W; Borg, A; Snijders, AP; Uhlmann, F and Singleton, MR (2017) Structure of the cohesin loader Scc2. Nature Communications 8, 13952
