Nicholas Luscombe
genetics
Francis Crick Institute
United Kingdom
Biography
Following a degree in natural sciences at Jesus College, University of Cambridge (1993-1996), Nick studied for a PhD with Janet Thornton at UCL (University College London) (1996-2000) on the basis for specificity of DNA-binding proteins. He then moved to Yale University, USA, as an Anna Fuller Postdoctoral Fellow with Mark Gerstein (2000-2005), He was a Group Leader at the EMBL-European Bioinformatics Institute (2005-2012) in Cambridge and built a computational biology laboratory with an emphasis on genomics and gene regulation. During this time, he joined the Okinawa Institute of Science & Technology as an Adjunct Faculty to establish a small group focused on developmental regulation (2011-present). He recently returned to UCL as a Chair in Computational Biology in the UCL Genetics Institute and holds a joint appointment as a Senior Winton Group Leader at the Francis Crick Institute, in recognition of the Winton Charitable Foundation's generous donation towards establishing the Francis Crick Institute. Nick was elected as an EMBO Member in 2013.
Research Interest
research focus genomics with a particular emphasis on yeast transcriptional regulation.
Publications
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Mifsud, B; Martincorena, I; Darbo, E; Sugar, R; Schoenfelder, S; Fraser, P and Luscombe, NM (2017) GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data. PLOS ONE 12, e0174744
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Kar, G; Kim, JK; Kolodziejczyk, AA; Natarajan, KN; Torlai Triglia, E; Mifsud, B; Elderkin, S; Marioni, JC; Pombo, A and Teichmann, SA (2017) Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression. Nature Communications 8, 36
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Hall, CE; Yao, Z; Choi, M; Tyzack, GE; Serio, A; Luisier, R; Harley, J; Preza, E; Arber, C; Crisp, SJ; Watson, PMD; Kullmann, DM; Abramov, AY; Wray, S; Burley, R; Loh, SHY; Martins, LM; Stevens, MM; Luscombe, NM; Sibley, CR; Lakatos, A; Ule, J; Gandhi, S and Patani, R (2017) Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS. Cell Reports 19, 1739-1749
