Steve Gamblin
Biochemistry
Francis Crick Institute
United Kingdom
Biography
Steve Gamblin trained in biochemistry (BSc and PhD) at Bristol University, studying enzymology and crystallography with Herman Watson. Postdoctoral studies with Stephen Harrison at Harvard mainly involved crystallography to look at HIV reverse transcriptase, SV40 virus and topoisomerase. Steve moved to the Medical Research Council's National Institute for Medical Research (NIMR; now part of the Francis Crick Institute) in 1994 to work in the newly established Division of Protein Structure. He was appointed Joint Head of the Division of Molecular Structure in 2005, and was appointed Director of Research at NIMR in 2011. He is a Fellow of the Academy of Medical Sciences, a member of EMBO, and has been awarded the Feldberg Prize for 2012. Steve was elected to a Fellowship of the Royal Society in 2011.
Research Interest
interested in determining the mechanisms that drive this exquisitely targeted modification. Increasing evidence points to the perturbation of epigenetic signalling systems in developmental diseases and cancer.
Publications
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Willows, R; Sanders, MJ; Xiao, B; Patel, BR; Martin, SR; Read, J; Wilson, JR; Hubbard, J; Gamblin, SJ and Carling, D (2017) Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells. Biochemical Journal 474, 3059-3073
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Peacock, TP; Benton, DJ; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; McCauley, JW; Barclay, WS and Iqbal, M (2017) Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion. Emerging Microbes & Infections 6, e11
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Peacock, TP; Benton, DJ; James, J; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; Barclay, WS and Iqbal, M (2017) Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics. Journal of Virology 91, e00218-00217
