Anna Katharina AÂ simon
Professor
Immunology
Kennedy Institute of Rheumatology Trust (Charing Cross Sunley Research Centre)
United Kingdom
Biography
Katja Simon is studying cell fate in the hematopoietic system. She trained as an Immunologist under Avrion Mitchison at the DRFZ Berlin and found that TH1 cytokines are found in excess in human autoimmune diseases in her PhD. As a postdoc at the Centre d'Immunologie Marseille Luminy, she investigated transcription factors regulating thymic cell death. During her second postdoc in Oxford she pursued her interest in cell fate, studying cell death molecules (Trail and FasL) in thymic selection, inflammation and tumour immunity. As a principal investigator, she set up an independent line of enquiry investigating autophagy, another cellular process determining cell fate, in the hemato-immune system. Her group discovered that autophagy, the main conserved cellular bulk degradation pathway, maintains healthy red blood cells, stem cells and memory T cells and promotes differentiation while preventing ageing of the hematopoietic system. Research interests: Immunology She published more than 80 articles
Research Interest
Immunology
Publications
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"1. Riffelmacher T, Richter FC, Simon AK. Autophagy dictates metabolism and differentiation of inflammatory immune cells. Autophagy (2017). 2. Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Anna Katharina A Simon. Molecular definitions of autophagy and related processes. EMBO J (2017) 36: 1811-1836. 3. Riffelmacher T, Simon AK. Mechanistic roles of autophagy in hematopoietic differentiation. FEBS J (2017) 284: 1008-1020. 4. Liao C, Ashley N, Diot A, Simon AK. Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations. Neurology (2017) 88: 131-142. 5. Simon AK, Clarke AJ. Non-canonical autophagy LAPs lupus. Cell Death Differ (2016) 23: 1267-1268.
