Alistair Lax
Mucosal & Salivary Biology
Kings College London
United Kingdom
Biography
Alistair Lax’s first degree was in Biochemistry at the University of Glasgow. He obtained his PhD on Dictyostelium discoideum development at ICRF (now Cancer Research UK) in London in 1979. After a year as a supply teacher in Inner London, he was appointed to a staff position at the Institute for Animal Health in Berkshire to work on the transmissible spongiform encephalopathy, scrapie. He later moved into bacterial pathogenesis, working first on Salmonella virulence, then with Pasteurella multocida. Analysis of the mitogenic P. multocida toxin led him into the analysis of cellular signalling pathways, in particular those associated with G-protein signal pathways. This work led to his interest in the role of bacterial toxins in cancer.
Research Interest
Bacterial toxins that interfere with cellular signalling; cellular microbiology; bacteria and cancer.
Publications
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Babb RC, Homer KA, Robbins J, Lax AJ. Modification of heterotrimeric G-proteins in Swiss 3T3 cells stimulated with Pasteurella multocida toxin. PloS one. 2012 Nov 5;7(11):e47188."
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Surguy SM, Duricki DA, Reilly JM, Lax AJ, Robbins J. The actions of Pasteurella multocida toxin on neuronal cells. Neuropharmacology. 2014 Feb 28;77:9-18.
