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Anthony Magee

Professor
Faculty of Medicine
National Heart Lung Institute
United Kingdom

Biography

Tony Magee is Professor of Membrane Biology at the National Heart and Lung Institute, Imperial College London, and Head of the Section of Molecular Medicine. Professor Magee trained in biochemistry and protein chemistry and began work on lipid modification of proteins as a post-doc in 1980. He continued to work in this field as an independent investigator at the MRC's NIMR (Mill Hill, 1983-2001) and Imperial College London (2001-present). Professor Magee is an established leader in the field of protein lipidation and has been invited to speak at many international conferences and organise several colloquia and conferences. He has made major contributions in protein prenylation (co-discovering the prenylation of Ras proteins), protein acylation (of Ras proteins and Src family kinases) and lipid rafts (identifying a key role in T cell receptor signaling). His current interests are in the enzymes catalyzing acylation of secreted proteins (e.g. Hedgehog proteins) and their role in cancer, in the functional role of protein acylation e.g. in signalling, and in novel applications of advanced light microscopy imaging.

Research Interest

Molecular Membrane Biology

Publications

  • Broncel M, Serwa RA, Ciepla P, et al., 2015, Myristoylation profiling in human cells and zebrafish., Data Brief, Vol:4, ISSN:2352-3409, Pages:379-383

  • Broncel M, Serwa RA, Ciepla P, et al., 2015, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development, Angewandte Chemie-international Edition, Vol:54, ISSN:1433-7851, Pages:5948-5951

  • Rodgers UR, Lanyon-Hogg T, Masumoto N, et al., 2016, Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells, Acs Chemical Biology, Vol:11, ISSN:1554-8929, Pages:3256-3262

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