Jonathan Baker

Biography

Dr Jonathan Baker is a Research Associate at the Airway Disease Section of the National Heart and Lung Institute. His research interests involve the investigation of oxidative stress induced miRNAs and their regualtion of the accelerated ageing phenotype in chronic obstructive pulmonary disease (COPD), understanding how they may regulate cellular senescence. Dr Baker studied Biochemistry as an undergraduate at Newcastle Unisversity, were he was awarded the Emmerson Biochemistry Research prize for his dissertation. Following the completion of his studies in 2010 he continued his studies at Newcastle Univeristy, onbatining his PhD in 2014. During his PhD he studied the role of a family of kinases, named Protein Kinase D, in the regulation of matrix metalloproteinase expression in osteoarthiris. This work was presented at the BSR in Birmingham, in which he was awarded the Young Investigator award for his presentation. After completion of his PhD Jonathan started working for Professor Peter Barnes and Dr Kaz Ito at the NHLI. During this time Jonathan has been studying the role of miRNAs in the regualtion of sirtuin-1 and sirtuin-6, understading the molecular mechanism which lead to the down-regulation of these putative anti-ageing proteins in patients with COPD.

Research Interest

pulmonary diseases, anti-ageing proteins,