Lisete M. Silva

Biography

Lisete M. Silva obtained her BSc and MSc degrees in Chemistry at the Faculty of Sciences, Porto University (Portugal). Her PhD degree in Biochemistry at University of Aveiro (Portugal) was under the Supervision of Professor Manuel A. Coimbra with co-supervisors Dr. Angelina Palma (NOVA University of Lisbon, Portugal) and Dr. José A. Ferreira (Portuguese Institute of Oncology Porto). Lisete’s first experience in the Glycosciences Laboratory was in 2014 as a visiting student during her PhD studies, funded by the Portuguese Foundation for Science and Technology. Her PhD was focused on structural analysis of lipopolysaccharides (LPSs) of Helicobacter pylori by mass spectrometry: GC-MS and ESI-MS/MSn, and development of microarrays of the LPSs for interrogation with carbohydrate recognizing proteins: plant and animal lectins and proteins of the immune system. The LPS microarrays are also being used for serological studies aimed at distinguishing H. pylori-infected and uninfected subjects. Lisete started her Research Associate post in the Glycosciences Laboratory in March 2015; and in November 2015 she was named Deputy Microarray Project Leader with responsibility for (a) running and maintaining the group’s microarray equipment and (b) performing glycan array analyses of proteins received from national and international collaborators. She has been closely involved in the construction and validation of a new version of a broad spectrum microarray of 896 glycan probes for the Wellcome-Trust supported Carbohydrate Microarray Facility for applications in high throughput analyses of proteins from various sources of biological and medical impact. Lisete’s current research involves the investigation of different formulations of lipid-linked glycan probes in neoglycolipid (NGL)-based microarrays, and the binding signals they elicit in microarray analyses.

Research Interest

Biochemistry