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Nicholas Kirkby

Researcher
Faculty of Medicine
National Heart Lung Institute
United Kingdom

Biography

Dr Kirkby is a cardiovascular pharmacologist who leads a group in the Vascular Biology section of the National Heart & Lung Institute. His research interests centre around vasoactive hormones in health and disease, using rigorous basic science approaches including complex in vivo and in vitro models coupled with cutting edge '-omics' and systems biology techniques to address clinical relevant questions. These are applied with a view to rapid translation of findings into new drugs and therapeutic approaches that benefit the treatment of cardiovascular disease. Dr Kirkby performed his undergraduate training at the University of Edinburgh where he received a 1st class honours degree in Pharmacology in 2005. He remained in Edinburgh to undertake a PhD in the laboratoroes of Prof. David Webb and Dr Patrick Hadoke, studying the roles of the endothelial hormones, particularly endothelin-1, in the response to vascular injury. He completed his first post-doctoral training in Edinburgh under the guidance of Dr Patrick Hadoke and Prof Robin Plevin (Strathclyde University) before joining Imperial College in 2010. In 2013, in recognition of his post-doctoral success, Dr Kirkby was awarded an Imperial College Junior Research Fellowship and returned in REF2014. Most recently, in 2015, he was awarded a highly prestigious British Heart Foundation Intermediate Basic Science Research Fellowship.

Research Interest

Genomics, Cardiology

Publications

  • Armstrong PCJ, Kirkby NS, Chan MV, et al., 2015, Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction, Blood, Vol:126, ISSN:0006-4971, Pages:E11-E18

  • Kirkby NS, Chan MV, Zaiss AK, et al., 2016, Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-kappa B and NFAT transcriptional pathways, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:434-439

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