Peter Cherepanov
Professor
Faculty of Medicine
National Heart Lung Institute
United Kingdom
Biography
Peter Cherepanov's laboratory focuses on the structural biology of chromatin function and its interactions with retroviral integration machinery. Using X-ray crystallography as the primary tool, the researchers aim to elucidate three-dimensional structures of the complex machineries involved in regulation of eukaryotic DNA replication, gene expression and chromatin stability. The results will aid in the development of small molecules and virus-based vectors for treatment of cancer.
Research Interest
Cancer
Publications
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Hughes S, Elustondo F, Di Fonzo A, et al., 2012, Crystal structure of human CDC7 kinase in complex with its activator DBF4, Nature Structural & Molecular Biology, Vol:19, ISSN:1545-9993, Pages:1101-+
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Maertens GN, Cook NJ, Wang W, et al., 2014, Structural basis for nuclear import of splicing factors by human Transportin 3, Proceedings of the National Academy of Sciences of the United States of America, Vol:111, ISSN:0027-8424, Pages:2728-2733
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Lesbats P, Engelman AN, Cherepanov P, 2016, Retroviral DNA Integration, Chemical Reviews, Vol:116, ISSN:0009-2665, Pages:12730-12757
