Remi Peyronnet

Biography

Dr Rémi Peyronnet is joining the Harefield Heart Science Centre from December 2012 as part of Cardiac Biophysics and Systems Biology group, headed by Prof Peter Kohl. Rémi studied physiology at the Limoges Faculty of Science and Technology (2000-2004), and then he completed his Master and PhD (2004-2009) at the Orsay Faculty of Science (Paris XI). During this time, he studied key components of mechano-transduction in higher plants and identified new mechanosensitive channels. This research was based at the Institute of Plant Sciences (CNRS, Gif-sur-Yvette) with Jean-Marie Frachisse in Hélène Barbier-Brigoo’ s group. In 2010, he won a AFM (Association Française contre les Myopathies) Postdoctoral Research Fellowship and joined Dr Eric Honoré at the Institute of Molecular and Cellular Pharmacology (IPMC) Sophia-Antipolis. He investigated role and relevance of mechano-transduction mechanisms in Autosomal Dominant Polycystic Kidney Disease (ADPKD). In 2013, he won an Imperial College’s Junior Research Fellowship to investigate cross talks between mechanotransduction pathways and clinically-relevant drugs. He is combining cell electrophysiology with single cell mechanical control approaches to achieve this research. From his first researches, Rémi is interested in how cells sense their environment and adapt their function to changes in mechanical states. He combines a strong background in electrophysiology, using a range of techniques for applying mechanical stimulation in vitro and in vivo, to assess acute effects and more slowly-occurring adaptive responses to mechanical stimulation, from the molecular level (single ion channel) up to cells and whole organisms (including plants, rodents, and human).

Research Interest

Systems Biology, physiology