Trevor Hansel

Biography

In 2009 Trevor Hansel became Medical Director of the Imperial Clinical Respiratory Research Unit (ICRRU) at St Mary's Hospital, having been Medical Director of the NHLI Clinical Studies Unit at the Royal Brompton Hospital from 1997-2009. He is also an Honorary Consultant Immunologist at St. Mary's Hospital in London. He obtained his medical degree in 1982 at the Welsh National School of Medicine, Cardiff and then completed higher specialist medical training in clinical immunology in Birmingham. From 1990-1993 Trevor performed clinical asthma research in Davos, Switzerland; developing methods for blood eosinophil isolation and sputum eosinophil surface marker assessment. Following this, he worked in respiratory drug development with Sandoz and Roche in Basel; working in project management and clinical development. In addition, he has regulatory experience from the Biotechnology Unit of the Medicines Control Agency (MCA) in London. Trevor has a specialist interest in phase II clinical testing of new anti-inflammatory therapies for asthma and COPD, and has worked on a variety of challenge models in patients. In particular he is working on novel non-invasive methods to sample the airways: using synthetic absorptive matrices to measure cytokines and chemokines in nasal and bronchial mucosal lining fluid. These sampling methods have been developed on nasal allergen challenge, and he is also working on challenges with viruses, cigarette smoke, and agonists for innate immunity (LPS and poly-IC). He also works on human whole blood challenge methods to demonstrate pharmacodynamic activity of anti-inflammatory drugs.

Research Interest

Immunology