Uma Anand
Researcher
Faculty of Medicine
National Heart Lung Institute
United Kingdom
Biography
My research interest is in neuronal plasticity, investigating ion channel/receptor expression utilizing immunostaining techniques in transfected cells, and sensory neurons from rats and humans in models of neuronal hypersensitivity. For functional studies I use calcium imaging in these cells, to identify novel drug targets and their mechanism of action, in pharmacological assays of potential drug molecules, for treating chronic pain. I use cell based assays for morphological effects of substances such as chemotherapy agents and toxins such as mycolactone in DRG neurons, especially useful for neurotoxicology studies. I am also involved in live cell nano imaging of neuronal growth cones using Scanning Ion Conductance Microscopy with Prof. Yuri Korchev. This work has led to several publications on modulators of novel targets including the TrkA inhibitor CT327 for treating psoriasis associated pruritis and the Angiotensin II subtype 2 receptor (AT2R) antagonist, EMA401, that have had successful outcomes in recent clinical trials.
Research Interest
Clinical trials
Publications
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Anand U, Sinisi M, Fox M, et al., 2016, Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer, Molecular Pain, Vol:12, ISSN:1744-8069
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Anand U, Cohen J, McMahon SB, Preferential Growth of Neonatal Rat Dorsal Root Ganglion Cells on Homotypic Peripheral Newe Substrates ln vitro, European Journal of Neuroscience, ISSN:1460-9568
