Nathan Brown
Senior Researcher
Medicinal Chemistry 1 (including Analytical Chemistry and In
The Institute Of Cancer Research
United Kingdom
Biography
Dr Nathan Brown holds an honours degree in computing from Robert Gordon University in Aberdeen. He conducted his doctoral research under Professor Peter Willett at the University of Sheffield and Dr Richard Lewis, then Head of Computer-Aided Drug Discovery at Eli Lilly & Co. On completing his doctoral research, he was awarded a Marie Curie Fellowship for two years working with Avantium in Amsterdam and Professor Johnny Gasteiger at the University of Erlangen-Nuremberg. He was subsequently one of the first to be awarded a prestigious Presidential Research Fellowship for three years, by Professor Mark Fishman, Global Head of Research at the Novartis Institutes for BioMedical Research. Dr Brown has extensive experience as a software designer and developer in many different programming languages. He has developed many novel algorithms to maximise the impact of the experimental data generated in medicinal chemistry and cancer biology. Dr Brown designed and implemented the first multiobjective de novo design algorithm, published in 2004.
Research Interest
His primary research interests are virtual ligand docking, de novo molecular design, multiobjective optimisation, molecular descriptors, predictive modelling, statistical learning, graph theory, machine learning, evolutionary algorithms, artificial life, molecular similarity and diversity, bioisosteric replacement and scaffold hopping. Dr Brown is on the editorial board of Advances in Drug Discovery and Development, and Frontiers in Chemistry: Theoretical and Computational Chemistry. He is also on the committees of the UK-QSAR and Chemoinformatics Group and the Chemical Information and Computer Applications Group of The Royal Society of Chemistry
Publications
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Firth, N.C., Atrash, B., Brown, N. & Blagg, J. (2015). MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation. Journal of chemical information and modeling, Vol.55(6), pp. 1169-1180.
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Brown, N. (2015). Chemoinformatics in the United Kingdom. Molecular informatics, Vol.34(9), pp. 578-579.
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Caldwell, J., liu, M., richards, M., brown, N., eccles, & raynaud, (2016). Synthesis and Evaluation of a 2,11-Cembranoid-inspired Library. Chemistry, Vol.22(16), pp. 5657-5664.
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Caldwell, J., liu, M., richards, M., brown, N., eccles, & raynaud, (2016). Synthesis and Evaluation of a 2,11-Cembranoid-inspired Library. Chemistry, Vol.22(16), pp. 5657-5664.
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Osborne, J.D., Matthews, T.P., McHardy, T., Proisy, N., Cheung, K.-., Lainchbury, M., Brown, N., Walton, M.I., Eve, P.D., Boxall, K.J., et al. (2016). Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: ( R )-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). Journal of medicinal chemistry, Vol.59(11), pp. 5221-5237.
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Meyers, J., Carter, M., Mok, N.Y. & Brown, N. (2016). On the origins of three-dimensionality in drug-like molecules. Future medicinal chemistry, Vol.8(14), pp. 1753-1767.
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Mok, N.Y. & Brown, N. (2017). Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure–Activity Relationship Information. Journal of chemical information and modeling, Vol.57(1), pp. 27-35.
