Deborah Charlesworth
Professor
BIOLOGICAL SCIENCES
The University of Edinburgh
United Kingdom
Biography
He is a professor and teaches Molecular Evolution and Diversity, Evolutionary Genomics, Evolution of Sex and Mating Systems.
Research Interest
Evolutionary and population genetics, particularly topics in the general area of the evolution of breeding systems. Linkage disequilibrium in the genome region containing the self-incompatibility alleles of the plant Arabidopsis lyrata, and estimation of this regions rate of genetic recombination (to test whether it is unusually low, since it contains the two incompatibility loci, one encoding the pollen recognition protein and one the pistil receptor). DNA sequence diversity at other loci in populations of this species, aimed at comparing genomic patterns of evolution with its close relative A. thaliana. Molecular evolution of sex chromosomes, including studies of the evolution of Y-linked genes in the white campion, Silene latifolia.
Publications
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Jordan, C., and D. Charlesworth, 2012 The potential for sexually antagonistic polymorphism in different genome regions. Evolution 66: 505–516. DOI: 10.1111/j.1558-5646.2011.01448.x
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Bergero, R., and D. Charlesworth, 2011 Preservation of the Y transcriptome in a 10MY old plant sex chromosome system. Current Biology 21: 1470-1474.
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S. Qiu, R. Bergero, A. Forrest, V. Kaiser, D. Charlesworth 2010 Nucleotide diversity in Silene latifolia autosomal and sex-linked genes. Proceedings of the Royal Soc. 277: 3283-3290 (doi:10.1098/rspb.2010.0606).
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D. Charlesworth 2006 Balancing selection and its effects on sequences in nearby genome regions. PLoS Genetics 2: e64 DOI: 10.1371/journal.pgen.0020064.
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Bergero, R., A. Forrest, E. Kamau, and D. Charlesworth. 2007. Evolutionary strata on the X chromosomes of the dioecious plant Silene latifolia: evidence from new sex-linked genes. Genetics 175:1945-1954.
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Asher D. Cutter, Scott E. Baird and Deborah Charlesworth. 2006 Patterns of nucleotide polymorphism and the decay of linkage disequilibrium in wild populations of Caenorhabditis remanei. Genetics 174: 901-913.
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Jesper S. Bechsgaard, Vincent Castric, Deborah Charlesworth, Xavier Vekemans, Mikkel H. Schierup. 2006. The transition to self-compatibility in Arabidopsis thaliana and evolution within S-haplotypes over 10 million years. Molecular Biology and Evolution 23: 1741-1750.
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Charlesworth, D,Wright, SI. (2001) Breeding systems and genome evolution. Current Opinion in Genetics & Development 11, 685-690.
