Linhua Pang
Division of Respiratory Medicine
The University of Nottingham
United Kingdom
Biography
Linhua Pang currently working as a Professor in the Department of Epidemiology and Public Health, University of Nottingham , United Kingdom.
Research Interest
Synthetic functions of airway structural cells (airway smooth muscle cells, fibroblasts, epithelial cells), particularly the expression and production of inflammatory cytokines, chemokines, growth factors, angiogenic factors, inflammatory enzymes and lipid mediators, and their role in the pathophysiology of asthma, idiopathic pulmonary fibrosis, COPD and cyctic fibrosis. Molecular mechanisms of transcriptional regulation of key genes in human airway structural cells, particularly epigenetic mechanisms, including transcription factor activation and promoter binding, histone modifications, promoter DNA methylation, epigenetic modifying enzyme activation and recruitment, and interactions between different epigenetic pathways. Molecular mechanism of action of drugs that target key gene expression and their therapeutic potential in in vitro cell model of respiratory diseases, providing the basis for further translational studies.
Publications
-
COWARD WR, WATTS K, FEGHALI-BOSTWICK CA, JENKINS G, PANG L. Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis Molecular and Cellular Biology. 30(12), 2874-2886 .(2010).
-
DENG X, XU M, YUAN C, YIN L, CHEN X, ZHOU X, LI G, FU Y, FEGHALI-BOSTWICK CA, PANG L. Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-κB and activator protein-1. Int J Biochem Cell Biol.. 45(7), 1366-76 .(2013).
-
COWARD WR, FEGHALI-BOSTWICK CA, JENKINS G, KNOX A, PANG L. A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis FASEB JOURNAL. 28(7), 3183-3196 .(2014).
