Nicholas Hannan
Division of Cancer and Stem Cells
The University of Nottingham
United Kingdom
Biography
Nicholas Hannan currently working as a Associate Professor in the Department of Cancer and Stem Cells, University of Nottingham , United Kingdom.
Research Interest
research interests are in mechanisms of endoderm development and disease. To study this we are using human stem cells to generate lung, liver, pancreatic and intestinal cells. We then use these cells to model early human development and understand mechanisms of cell fate choice. In addition to developmental studies we are also using these cells for disease modelling. We have also developed 3D culture platforms for the culture of primary human cells from the liver and intestines. Using this technology combined with our stem cell platforms we are modelling (with help from collaborators) several major diseases that affect endodermal organs including Crohn's disease, ulcerative colitis, idiopathic pulmonary fibrosis, cystic fibrosis, hepatitis B infection, drug induced liver injury and non-alcoholic fatty liver disease.
Publications
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HANNAN NRF, SAMPAZIOTIS F, SEGERITZ C, HANLEY NA, VALLIER L. Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells. Stem cells and development. 24(14), 1680-90 .(2015).
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FORBESTER JL, HANNAN N, VALLIER L, DOUGAN G. Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System. Methods in molecular biology (Clifton, N.J.). (In Press.) .(2016).
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SAMPAZIOTIS F, DE BRITO MC, GETI I, BERTERO A, HANNAN NR, VALLIER L. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nature protocols. 12(4), 814-827 .(2017).
