Rob Delahay
Nottingham Digestive Diseases Centre
The University of Nottingham
United Kingdom
Biography
Rob Delahay currently working as a Assistant Professor in the Department of Digestive Diseases Centre, University of Nottingham , United Kingdom.
Research Interest
Numerous bacterial pathogens employ specialized secretion systems to interact with and modify the host cellular environment. Our research is focused on the functional characterisation of two such secretion systems; the type III secretion system (T3SS) of the pediatric diarrheal pathogen enteropathogenic Escherichia coli (EPEC), and two functionally disparate type IV secretion systems (T4SS) of the gastric pathogen Helicobacter pylori. Working within the Centre for Biomolecular Sciences (CBS) building (http://www.nottingham.ac.uk/cbs/index.aspx), we use an extensive array of molecular and protein biochemical techniques, together with in vitro models of infection, epifluorescence microscopy and comprehensive bioinformatics analyses. Our main projects aim to dissect key stages in the host-pathogen interaction by characterisation of major bacterial virulence determinants which promote successful host colonisation and predispose towards disease. 
Publications
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DELAHAY RM, RUGGE M. Pathogenesis of Helicobacter pylori infection. Helicobacter. 17 Suppl 1, 9-15 .(2012).
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GROVE JI, ALANDIYJANY MN, DELAHAY RM. Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of helicobacter pylori The Journal of Biological Chemistry. 288(37), 26385-26396 .(2013).
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ALANDIYJANY MN, CROXALL NJ, GROVE JI, DELAHAY RM. A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA. PloS one. 12(7), e0182144 .(2017).
